Can Hamotzi be said on bread that is made with baking powder and baking soda and not yeast? Is yeast integral to its being considered bread?
Any bread made from the five grains (wheat, rye, oat, barley, spelt) will require Hamotzi.
Many make hamotzi on matzo which does not contain yeast (and all make hamotzi on matzo on Pesach), so yes you can make Hamotzi on bread without yeast. Baking powder and baking soda should not detract from Hamotzi.