Tosefot Yom Tov ad loc. writes that logically it should apply to all kinds of nega'im, as the reasons for not being definitive regarding house-tzara'at apply equally well to other forms of tzara'at.
However, he does entertain the possibility that it only applies to house-tzara'at (and notes that one can infer as much from Rambam). If that is the case, he ...
The Gemara YOMA 78b lists great rabbis who would go out on YK with cork or reed sandals.
The question is how to understand the following statement regarding a prosthetic leg
יומא דף עח עמוד ב
אלא אמר רבא: לעולם דכולי עלמא מנעל הוא
RAVA would seem to indicate that a wooden prosthetic leg is an issue even though it is not leather.
Tur (and Bais Yosef) ...
Maybe because of this (but this is only for men)
Shulchan Aruch Harav 619.18 (from the Shalo)
...In addition, one should make a point of not covering himself with [so many] blankets and spreads that [his body] will be excessively warmed. One should at least leave his legs uncovered, as alluded to by the uncovering of Boaz’ legs, so that one’s body will ...