The Zohar 1:117a says:
וּבְשִׁית מְאָה שְׁנִין לִשְׁתִיתָאָה יִתְפַּתְּחוּן תַּרְעֵי דְחָכְמְתָא לְעֵילָא וּמַבּוּעֵי דְחָכְמְתָא לְתַתָּא
In the six hundredth year to the sixth millennium, the upper gates of wisdom will open up, and the lower springs of wisdom will open up.
Did any contemporary Rabbis of that time discuss this Zohar in relation to their surroundings?