Early editions of the Talmud did not have page numbers. (Early commentators give citations to chapters.) When did page numbering begin and, if today's page numbering differs, when was the page numbering finalized, and who established these page numbers?
The most commonly used pagination of the Talmud was printed by Daniel Bomberg in 1523:
The Bomberg edition of the Talmud established the standard both in terms of page layout as well as pagination (with the exception of the tractate Berachot which follows Bomberg’s second edition). Prior to the printing of the Talmud, manuscripts had no standard page division, and the Talmud text usually did not appear on the same page as the commentaries, which were contained in separate codices. The standard page layout in use in all conventional editions of Talmud today (also the accepted method of citing a Talmudic reference) follows the pagination of Bomberg’s 1523 publication. (Wikipedia)