The Gemara in Sanhedrin 90b relates:
(Source from Sefaria.org)
.....שאלה קליאופטרא מלכתא את ר"מ
Queen Cleopatra asked Rabbi Meir.....
What Queen Cleopatra was this?
Based on this, it must be that she was a different Queen Cleopatra1, but over whom or what was she queen?
1. And not the queen of Egypt