Lo Aleinu. Let's say someone's friend's teen-age daughter died from a terrible sickness. The parents have been distraught and "disabled" for year because of the emotional trauma. They isolate themselves at home for the most part, and they are unable to place a headstone on their daughter's grave because it is too painful for them.
Can one say misheberach l'cholim for such a situation? I'm thinking, perhaps, yes, because the end of the prayer says refu'at hanefesh - a healing of the spirit / soul.