Suppose someone is making a huge 50-gallon vat of cholent. Accidentally, an entire bag of milk breaks and spills into the cholent. There is more than 60x as much meat cholent as there is milk, so the milk should theoretically be batel b'shisim. But does the fact that a non-negligible amount of milk fell into the pot (as opposed to a couple of drops into a smaller pot) change anything?
The Rambam (MT Ma'achalot Asurot 9:10) writes
If the milk fell into the sauce or onto all the pieces and it was not known on which piece [the milk] fell he should stir the entire pot so that all its contents will be mixed [thoroughly]. If the flavor of milk [can be detected] in the entire pot, it is forbidden. If not, it is permitted. If a gentile to taste [the pot] whom we can rely on cannot be found, we require a measure of sixty whether for meat in milk or milk in meat. If there is one measure in sixty, it is permitted. If there is less than sixty, it is forbidden.
Therefore mixing the pot up to the point that the milk is dissolved into the mixture is enough to make the cholent kosher as long as there was 60 times the quantity of milk and if you cannot identify the milk anymore.