One example that is utterly irreverent yet very well done and funny is the Simpsons episode done up as a blatt of gemera. (As a positive aspect, his use of B'Laz for Rav Shmuel David Ha'Tzair, as "Candyman" actually gave me insight into what the whole point of B'Laz means in Rashi).
Looking for other good online sources. I know I had seen around yeshiva some little pamphlets each year at Purim, but no idea where to get them.
Edit: I looked at the PDF's linked of Mesechet Purim, but I was remembering one in Vilna Shas formatting.