Per this answer, the Abarbanel agreed with natural slavery as a consequence of the curse on Canaan.
Ironically, according to historian David Brion Davis, Abarbanel played a pivotal role in providing the conceptual basis for black slavery: "[...] the great Jewish philosopher and statesman Isaac ben Abrabanel, having seen many black slaves both in his native Portugal and in Spain, merged Aristotle's theory of natural slaves with the belief that the biblical Noah had cursed and condemned to slavery both his son Ham and his young grandson Canaan. Abravenel concluded that the servitude of animalistic black Africans should be perpetual."
I found the book, but its source is another book - Jews and Blacks in the Early Modern World by Jonathan Schorsch. And while the chapter on the Abarbanel is towards the beginning, the Cambridge sample only goes up to the beginning of that chapter.
Does anyone have a source - for this take on the Abarbanel or otherwise?