The Ohr HaChaim HaKadosh has a famous piece on Devarim 8:1 where it writes:
כׇּל־הַמִּצְוָ֗ה אֲשֶׁ֨ר אָנֹכִ֧י מְצַוְּךָ֛ הַיּ֖וֹם תִּשְׁמְר֣וּן לַעֲשׂ֑וֹת לְמַ֨עַן תִּֽחְי֜וּן וּרְבִיתֶ֗ם וּבָאתֶם֙ וִֽירִשְׁתֶּ֣ם אֶת־הָאָ֔רֶץ אֲשֶׁר־נִשְׁבַּ֥ע ה' לַאֲבֹתֵיכֶֽם׃
You shall faithfully observe all the Instruction that I enjoin upon you today, that you may thrive and increase and be able to possess the land that the LORD promised on oath to your fathers.
The Ohr HaChaim writes there:
He resorted to a way of illustrating his point which is incontrovertible, based on the Zohar volume one page 170. According to the Zohar man has 248 bones and 365 sinews. G-d commanded us 365 negative commandments and 248 positive commandments, one each to correspond to each of these parts of our body. If one suffers a pain or hurt in one of his bones or sinews he should examine which one of the commandments he had neglected so that the pain in question might be due to such neglect. A man will not be satisfied if in response to his cries of pain caused by the afflicted bone he is told by his doctor that seeing that 247 of his bones do not hurt him he should not really be complaining but count his blessings. Similarly, we must relate to each one of the 613 commandments. We cannot pride ourselves merely on the commandments we do observe but must be keenly aware of the damaging effect on our spiritual health of any commandment which we fail to observe when we have the opportunity. All of these considerations are included in Moses' reference to the need for us to observe the whole commandment, both the negative part and the positive part. The reason for this is למען תחיון, "so that you will live and multiply and come and inherit the land." Inheritance of the land of Israel is conditional on מצוה observance, which in turn is the guarantee of our spiritual and physical wellbeing. (Sefaria translation, my emphasis)
He mentions this point also earlier with his commentary on Vayikra 18:4
The Ramchal also brings out this point in his Kalach Pischei Chochmah 17:12 and introduces it by stating:
ועיקרו בסוד התרי"ג, שהוא כל בנין האדם
And this is the fundamental secret of the 613 mitzvos, that they comprise the structure of man.
In addition Rav Chaim Vital zt"l brings down in Shaar HaKavanos shaar alef, cheilek alef the following:
וכל אבר מן רמ"ח איברים נזון ממצוה פרטית המתיחסת לאותו אבר וכאשר יחסר לאדם קיום איזה מצוה גם האבר הפרטי המתיחס למצוה יחסר ממונו מזונו
And each limb of the 248 limbs is nourished from an individual mitzvah that relates to each limb. And when a person fails to do that particular mitzvah, that individual limb will lack its proper nourishment.