"...Years after, Rabbi Natan encountered Elijah the prophet and said to him: What did the Holy One, Blessed be He, do at that time, when Rabbi Yehoshua issued his declaration? Elijah said to him: The Holy One, Blessed be He, smiled and said: My children have triumphed over Me; My children have triumphed over Me." Bava_Metzia.59b
In this discourse, a relatively minor issue of ritual purity of utensils was discussed. And God was happy to accept Rabbis' triumph over His divine laws.
Would God be equally happy if the sages canceled more severe issues, such as Shabbat, or allowed some Arayot?