Who knows twenty-two?
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22 blemishes that invalidate an Olah (offering). (Likutei HaGra Shebimedrash Tadshei)
22 letters in the aleph-bet
22 are the customary number of lines in a mezuzah (Shulchan Aruch, Yoreh De'ah 288:11).
22 times it says "Ashrei" in Tehillim. (VaYiklrah Rabbah, Parshasah 10, Medrash Shohar Tov, 1)
22 cups (Givi'im) on the Menorah. (Menahos, Daf 28)
22 years that R' Akiva served Nachum Ish Gam Zu (Bereishis Rabba 22:2)
22 things were created in the world in the six days of creation... (Medrash Tadshei, 6)
Per the Medrash Breishis Rabsi Parshas Chaya Sara 23:1 which lists 22 Isha Ksheiras.
כ"ב נשים כשרות היו בעולם ואלו הן שרה, רבקה, רחל, לאה, סרח בת אשר, יוכבד, מרים, בתיה בת פרעה, דבורה, צללפונית אשת מנוח, חנה, אביגיל, מיכל, בת שבע, אבישג, חולדה הנביאה, יעל, אסתר.
חטה (wheat) has the gematria of 22 corresponding to the number of letters of the Aleph Beis which might explain why R. Yehudah says in Berachos 40a that the Tree of Knowledge was חטה.
Twenty two were the years of Ya'akov's separation, first from his parents, and then from Yosef.
(Hat-tip: my daughter)
Twenty two years is the maximum amount of time in which one should look forward to the fulfillment of his dream, as derived from Yosef whose dreams of his family bowing to him took 22 years to be fulfilled (Brachos 55b).
Rachel and Leah were 22 when they married Yaakov. - Seder Olam Rabbah 74:4