Who knows twenty-two?
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חטה (wheat) has the gematria of 22 corresponding to the number of letters of the Aleph Beis which might explain why R. Yehudah says in Berachos 40a that the Tree of Knowledge was חטה.
Twenty two were the years of Ya'akov's separation, first from his parents, and then from Yosef.
(Hat-tip: my daughter)