As we are often told, Antisemitism is "Heavenly decree", inevitable consequence of the very existence of the Jewish people. In the Torah (e.g. Deut. 28:64-66), G-d promises to hunt us down personally for our misdeeds through wild animals or other nations.
However, factually, it appears that there's some objective base for the perceived hatred toward the Jews, based on our traditional teachings that not only deal with praising the virtues of the people of Israel but also condemning, degrading and maybe even humiliating other nations.
Did any of our Rabbis see the empirical base for Antisemitic accusations in our sources and tried to offer practical ways of dealing with it?