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Do sociopaths/psychopaths lack “דעת” of Good and Evil?

As YeZ points out in this answer, "daat" is the Knowledge of Good and Evil. Do sociopaths and/or psychopaths lack the דעת of the distinction between good and evil?
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At what point can you assume senility?

In my experience it is rare to see a Rosh Yeshiva or other prominent Rabbi declared to be senile and no longer working at full mental capacity. Recently such a proclamation was made about one Rosh ...