259 years passed from when Hashem told Avraham, "You shall most certainly know [that your descendants will be strangers in a strange land...]," until Yaakov settled "in the land of his forefathers' sojourn (מגורי)" - which has the numerical value 259.
[Bereishis Rabbah 84:5. Matnos Kehunah and Etz Yosef there point out that it is hard to understand how this could be so, since the Covenant Between the Parts was in Avraham's seventieth year (2018 since Creation), and from then until Yaakov returned home, in 2207/8, is less than two hundred years. They suggest that it may be counting from Avraham's birth (1948-2207), or the period from the Dispersal - when Avraham first fully recognized Hashem, at age 48 - to Yaakov's passing (1996-2255).]
tšˁh wḥmšym wmˀtym - my ywdˁ. – Alex Jul 8 '11 at 14:44