If I have a Muktzeh item in a drawer, can I still get my shirts out of that drawer on Shabbat?
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See this discussion by Rabbi Dovid Ostroff. The drawer is a basis for that which is mutar and assur, so it depends which is more important, which is defined by Rav Moshe Feinstein based on his present needs and by Rav Shlomo Zalman Aurbach as a more absolute level of importance.