Is there a book that serves as a practical guide in English to applying the Brisker method of learning Gemara?
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The Brisker Derech: A Practical Guide by Moshe Wachtfogel goes through practical applications of the Brisker approach. It seems to be published by Feldheim, but I could not find it on their site.
I have not read through this work, but a cursory look inside prompted me to purchase this book for a friend. I purchased it at a local book store.
There's also a very nice book called Understanding Reb Chaim by Rabbi Yonoson Hughes (Israel, 2010). In it, the author translates and provides extensive commentary on ten of the maamarot from Reb Chaim's magnum opus.