Who knows two hundred eighty-one?
?אחד ושמונים ומאתים - מי יודע
In the spirit of the song "Echad - mi yodeya", please post interesting and significant Jewish facts about the number 281.
The lazy gematria on this one could be a splendid cure if you can't think of anything else.
Check out mi-yodeya-series for the previous two hundred eighty entries in this ongoing series.
Please include sources for your information wherever possible, as with all other answers on this site.