If I poked myself with a knife and possibly got blood on it; does it have to be kashered.
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There's talk about whether a slaugher knife remains fully kosher, but that discussion is always about whether the blood heat of the animal (did you know that the duck as the highest internal temperature of kosher animals in the literature?) "cooks" the blood into the knife. Human blood heat is certainly less than "yas soledes bo" (the temperature at which your hand would get uncomfortable), so the blood doesn't get cooked or otherwise driven in. Just wash the knife really clean, and you're fine.
(Weirdly enough, human blood is only a rabbinic prohibition, not Biblical. But the reason the knife is okay here is because it didn't absorb.)
The consumption of human presents a number of halachic problems/prohibitions but they are not related to kashrus strictly speaking.
Human blood is prohibited because of Maris Ayin, it is not even strictly speaking a "Rabbinic prohibition". As such there is, I believe, no concept of tam k'ikkar (the taste is like the forbidden substance). As such while it is prohibited to eat bread which has blood from one's gums on it, such blood would not impart a forbidden taste to utensils. (Shulchan Aruch, Yoreh Deah 66:10)